I just had a biopsy this afternoon. I heard horror stories and stories of 'it is no big deal'. Right before the biopsy, as I was waiting frantically and anxiously, I asked the nurse what to expect. She said it isn't pleasant, but it feels like a really bad menstrual cramp plus some extra pain. That is exactly what it felt like. The doc told me everything as he did it, and there was cramping and some other pain that can be compared to a pap smear, maybe slightly worse. But not nearly as bad as expected. There was bleeding afterwards and a pad is necessary. The cramping for me lasted about 2 hours and then I was fine. I plan to rest up all day tomorrow just in case. But I was very relieved to hear the doc say that I was finished and I really didn't blow a gasket. Not a walk in the park, but I've had worse things done. It all depends on your tollerance. I had 2 percocets and a xanax before hand, but I'm used to those meds due to an ongoing back problem. They advised 2 advil, but to me that seemed ridiculous. If you have percocet, take 1 or 2. Otherwise, good luck and just breath in and our slowly and try to be calm and relaxed throughout the procedure and you'll do fine.