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Oasis Dating It is helpful to attempt to understand the nature of your depression. Depression is a physical and mental condition. The brain will have a decrease in serotonin when a person has been anxious or stressed out for a while. When serotonin is low, the symptoms of depression increase. Medications such as anti-depressants are prescribed for depression, as this encourages the brain to step up its production of serotonin. However, serotonin levels can be elevated through many natural ways.