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Genetic events in the development of colon cancer

Posted by aranganathan on Thu, 03 Mar 2011

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Genetic events in the development of colon cancerColon cancer has been shown to progress through a series of well defined pathological stages. Initially, there is widespread hyperplasia in the colonic epithelium followed by the development of tumours in hyperplastic areas. Progressive stages of small, intermediate and late non-malignant adenomas have been identified leading to malignant carcinoma and finally metastasis. Oncogenes are activated by genetic changes, mutations or translocations, to ... Read More

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APC | LOH | FAP | DCC |

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